Nexium Gastric antisecretory treatment when not oral route 20-40 mg parenterally once daily.
Reflux oesophagitis 40 mg once daily.
Symptomatic treatment of reflux disease, healing of gastric ulcers associated w/ NSAID therapy & prevention of gastric & duodenal ulcers associated w/ NSAID therapy 20 mg once daily.
Prevention of gastric & duodenal ulcer rebleeding 80 mg as bolus infusion over 30 min followed by continuous IV infusion of 8 mg/hr over 72 hr.
Severe hepatic impairment GERD Max daily dose: 20 mg.
Bleeding ulcers 80 mg as bolus dose followed by 4 mg/hr continuous IV infusion dose for 71.5 hr.
Nexium MUPS Adult & adolescent from 12 yr Erosive reflux esophagitis 40 mg once daily for 4-8 wk.
Long-term management of patient w/ healed esophagitis to prevent relapse & prevention of gastric & duodenal ulcers associated w/ NSAID therapy in patient at risk 20 mg once daily.
Symptomatic treatment of GERD 20 mg once daily in patient w/o esophagitis. Continue w/ 20 mg once daily on demand if control has been achieved.
Adult Eradication & healing of H pylori-associated duodenal ulcer & prevention of peptic ulcer relapse in patient w/ H pylori-associated ulcers 20 mg w/ amoxicillin 1 g & clarithromycin 500 mg bd for 7 days.
Healing of gastric ulcers associated w/ NSAID therapy 20 mg once daily for 4-8 wk.
Prevention of peptic ulcer rebleeding after prolonged IV treatment 40 mg once daily for 4 wk.
Zollinger-Ellison syndrome Initially 40 mg bd, individually adjusted & continued as clinically indicated. Dose range: 80-160 mg daily. Doses >80 mg should be divided & given bd.
Severe hepatic impairment Max: 20 mg.
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